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FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

8 Aug 2018

Abstract excerpt

Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age-related dysregulation of expression; they are emerging as potential influences on aging and longevity. The upstream drivers of these alterations are still unclear but may involve aberrant cellular signaling. We...

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PMID: 30088951
DOI: 10.1096/fj.201801154r

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