Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence

Abstract excerpt

BACKGROUND: Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory network, including genome-wide alternative splicing machinery, involved in endothelial cell senescence is lacking. RESULTS: We thoroughly described the transcriptome landscape of replicative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angiogenesis and VEGF in Cancer
• Share to Barrier Structure and Function Studies
• Share to Telomeres, Telomerase, and Senescence