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Article

Age-Dependent Modifications of Gene Expression in Human Fibroblasts

1 Jan 1998

Abstract excerpt

Normal human fibroblasts exhibit a limited proliferative potential in culture. When populations are serially subcultured, they grow well initially, but ultimately reach a stage when they are no longer able to proliferate in response to mitogenic stimuli. This state is designated "replicative senescence". In addition to failure to proliferate, numerous morphological and physiological changes characterize the...

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PMID: 9673450
DOI: 10.1615/critreveukargeneexpr.v8.i1.30

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