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Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling

5 Dec 2006

Abstract excerpt

Normal somatic cells have a limited replicative lifespan, and serial subcultivation ultimately results in senescence. Senescent cells are irreversibly growth-arrested and show impaired responses to mitogens. Activation of the ERK signaling pathway, an absolute requirement for cell proliferation, results in nuclear relocalization of active ERKs, an event impaired in senescent fibroblasts. This impairment coincides...

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PMID: 17145763
DOI: 10.1074/jbc.m604955200

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