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Article

Senescent phenotype can be reversed by reduction of caveolin status.

The Journal of biological chemistry - 25 Jul 2003

Cho Kyung A, Ryu Sung Jin, Park Jeong Soo, Jang Ik Soon, Ahn Jeong Soo, Kim Kyung Tae, Park Sang Chul

Abstract excerpt

Hyporesponsiveness to growth factors is one of the fundamental characteristics of senescent cells. We previously reported that the up-regulation of caveolin attenuates the growth factor response and the subsequent downstream signal cascades in senescent human diploid fibroblasts. Therefore, in th...

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Identifiers

PMID: 12730243
DOI: 10.1074/jbc.M208105200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12730243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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