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Article

Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2005

Kyoung Kim Hyun, Kyoung Kim Yu, Song In-Hwan, Baek Suk-Hwan, Lee Seung-Rock, Hye Kim Jung, Kim Jae-Ryong

Abstract excerpt

The signaling pathway of insulin/insulin-like growth factor/phosphatidylinositol-3 kinase/Akt/forkhead transcription factors is known to control life span and senescence in organisms ranging from yeast to mice. The FOXO family of forkhead transcription factors, FOXO1, FOXO3a, and FOXO4, play a critical role in this signal transduction pathway. However, the impact of FOXO3a activation on life span of primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15741276
DOI: 10.1093/gerona/60.1.4

Genes

FOXO1
FOXO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts.PMID 15741276Read ↗

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