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Article

The transcription factor <scp>S</scp>p1 is responsible for aging‐dependent altered nucleocytoplasmic trafficking

28 Sept 2012

Abstract excerpt

Hyporesponsiveness to external signals, such as growth factors and apoptotic stimuli, is a cardinal feature of cellular senescence. We previously reported that an aging-dependent marked reduction in nucleocytoplasmic trafficking (NCT)-related genes could be responsible for this phenomenon. In searching for the mechanism, we identified the transcription factor, Sp1, as a common regulator of NCT genes, including...

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PMID: 23013401
DOI: 10.1111/acel.12012

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