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Article

Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2013

Tivey Hannah S E, Rokicki Michal J, Barnacle James R, Rogers Matthew J, Bagley Mark C, Kipling David, Davis Terence

Abstract excerpt

Ataxia-telangiectasia and rad3 (ATR)-related Seckel syndrome is associated with growth retardation and premature aging features. ATR-Seckel fibroblasts have a reduced replicative capacity in vitro and an aged morphology that is associated with activation of stress-associated p38 mitogen-activated...

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Identifiers

PMID: 23401567
DOI: 10.1093/gerona/gls336
PMCID: PMC3738025

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23401567-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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