Article
Oncogene c-fos and mutant R175H p53 regulate expression of Nucleophosmin implicating cancer manifestation.
The FEBS journal - 1 Sept 2018
Senapati Parijat, Dey Suchismita, Sudarshan Deepthi, Das Sadhan, Kumar Manoj, Kaypee Stephanie, Mohiyuddin Azeem, Kodaganur Gopinath S, Kundu Tapas K
Abstract excerpt
Nucleophosmin (NPM1) is a nucleolar protein that is frequently overexpressed in various types of solid tumors. NPM1 is involved in several cellular processes that might contribute significantly to the increased proliferation potential of cancers. Previous reports suggest that NPM1 expression is highly increased in response to mitogenic and oncogenic signals, the mechanisms of which have not been elucidated...
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