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Article

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development.

Oncotarget - 23 Aug 2016

Barbieri Elisa, Deflorian Gianluca, Pezzimenti Federica, Valli Debora, Saia Marco, Meani Natalia, Gruszka Alicja M, Alcalay Myriam

Abstract excerpt

Nucleophosmin (NPM1) is a ubiquitous multifunctional phosphoprotein with both oncogenic and tumor suppressor functions. Mutations of the NPM1 gene are the most frequent genetic alterations in acute myeloid leukemia (AML) and result in the expression of a mutant protein with aberrant cytoplasmic localization, NPMc+. Although NPMc+ causes myeloproliferation and AML in animal models, its mechanism of action remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27486814
DOI: 10.18632/oncotarget.10878
PMCID: PMC5342418

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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