Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.

Oncogene - 22 Nov 2007

Cheng K, Grisendi S, Clohessy J G, Majid S, Bernardi R, Sportoletti P, Pandolfi P P

Abstract excerpt

Mutations leading to aberrant cytoplasmic localization of Nucleophosmin 1 (NPM1) have been recently identified as the most frequent genetic alteration in acute myelogenous leukemia. However, the oncogenic potential of this nucleophosmin mutant (NPMc+) has never been established, which casts doubt on its role in leukemogenesis. By performing classical transformation assays, we find that NPMc+, but not wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenovirus E1A Proteins
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Cytoplasm

Share to Gene Silencing

Share to Leukemia

Share to Nucleophosmin

Share to Oncogenes

Source

Identifiers

PMID: 17546053
DOI: 10.1038/sj.onc.1210549

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.PMID 17546053Read ↗

The Myc-Nucleophosmin-ARF network: A complex web unveiledSemantic proximity Read ↗

Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor ProteinSemantic proximity Read ↗

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.Semantic proximity Read ↗

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia.Semantic proximity Read ↗

Role of nucleophosmin in acute myeloid leukemia.Semantic proximity Read ↗

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.Semantic proximity Read ↗

[Nucleophosmin mutations in hematological malignancies - review].Semantic proximity Read ↗

Functions of the native NPM1 protein and its leukemic mutant.Semantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

Nucleophosmin: from structure and function to disease development.Semantic proximity Read ↗

Type F mutation of nucleophosmin 1 Acute Myeloid Leukemia: A tale of disorder and aggregation.Semantic proximity Read ↗

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.