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Article

Role of nucleophosmin in acute myeloid leukemia.

Expert review of anticancer therapy - 1 Sept 2009

Meani Natalia, Alcalay Myriam

Abstract excerpt

Nucleophosmin (NPM) is a nucleolar phosphoprotein implicated in the regulation of multiple cellular functions, which possesses both oncogenic and tumor-suppressor properties. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemias with mutated NPM1 have distinct...

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Topics

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Share to Cytoplasm
Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Prognosis

Share to Translocation, Genetic

Source

Identifiers

PMID: 19761432
DOI: 10.1586/era.09.84

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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