Article
Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.
The Journal of biological chemistry - 29 Mar 2013
Ando Koji, Tsushima Hideki, Matsuo Emi, Horio Kensuke, Tominaga-Sato Shinya, Imanishi Daisuke, Imaizumi Yoshitaka, Iwanaga Masako, Itonaga Hidehiro, Yoshida Shinichiro, Hata Tomoko, Moriuchi Ryozo, Kiyoi Hitoshi, Nimer Stephen, Mano Hiroyuki, Naoe Tomoki, Tomonaga Masao, Miyazaki Yasushi
Abstract excerpt
Myeloid ELF1-like factor (MEF/ELF4), a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers. Here, we report a mechanism by which MEF/ELF4 may be activated by a common leukemia-associated mutation in the nucleop...
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