Article
Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.
Blood - 22 Apr 2010
Bolli Niccolò, Payne Elspeth M, Grabher Clemens, Lee Jeong-Soo, Johnston Adam B, Falini Brunangelo, Kanki John P, Look A Thomas
Abstract excerpt
Mutations in the human nucleophosmin (NPM1) gene are the most frequent genetic alteration in adult acute myeloid leukemias (AMLs) and result in aberrant cytoplasmic translocation of this nucleolar phosphoprotein (NPMc+). However, underlying mechanisms leading to leukemogenesis remain unknown. To address this issue, we took advantage of the zebrafish model organism, which expresses 2 genes orthologous to human...
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