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Article

Nucleophosmin: from structure and function to disease development.

BMC molecular biology - 24 Aug 2016

Box Joseph K, Paquet Nicolas, Adams Mark N, Boucher Didier, Bolderson Emma, O'Byrne Kenneth J, Richard Derek J

Abstract excerpt

Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27553022
DOI: 10.1186/s12867-016-0073-9
PMCID: PMC4995807

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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