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Article

Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line.

International journal of molecular sciences - 11 Jul 2022

Cela Ilaria, Cufaro Maria Concetta, Fucito Maurine, Pieragostino Damiana, Lanuti Paola, Sallese Michele, Del Boccio Piero, Di Matteo Adele, Allocati Nerino, De Laurenzi Vincenzo, Federici Luca

Abstract excerpt

Nucleostemin (NS; a product of the GNL3 gene) is a nucleolar-nucleoplasm shuttling GTPase whose levels are high in stem cells and rapidly decrease upon differentiation. NS levels are also high in several solid and hematological neoplasms, including acute myeloid leukaemia (AML). While a role in telomere maintenance, response to stress stimuli and favoring DNA repair has been proposed in solid cancers, little or...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 35886999
DOI: 10.3390/ijms23147655
PMCID: PMC9317519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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