Nucleophosmin and cancer.

doi:10.1038/nrc1885

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Article

Nucleophosmin and cancer.

Nature reviews. Cancer - 1 Jul 2006

Grisendi Silvia, Mecucci Cristina, Falini Brunangelo, Pandolfi Pier Paolo

Abstract excerpt

NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to...

Topics

Animals
Cell Transformation, Neoplastic
Humans
Mutation
Neoplasms
Nuclear Proteins
Nucleophosmin
Proto-Oncogene Mas

Source

Open in PubMed

Identifiers

PMID: 16794633
DOI: 10.1038/nrc1885

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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