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Article

Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.

Molecular & cellular proteomics : MCP - 1 Nov 2018

Li Zonghong, Liu Hongyang, Niu Zhangjing, Zhong Wen, Xue Miaomiao, Wang Jifeng, Yang Fuquan, Zhou Yue, Zhou Yifa, Xu Tao, Hou Junjie

Abstract excerpt

Chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. The underlying mechanisms, such as endoplasmic reticulum (ER) stress, oxidative stress and metabolic disorders, have been reported before; however, the time sequence of these molecular events is not fully understood. Here, using isobaric...

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Identifiers

PMID: 30082485
DOI: 10.1074/mcp.RA118.000698
PMCID: PMC6210228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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