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Article

PHLPP: a putative cellular target during insulin resistance and type 2 diabetes

20 Apr 2017

Abstract excerpt

Progressive research in the past decade converges to the impact of PHLPP in regulating the cellular metabolism through PI3K/AKT inhibition. Aberrations in PKB/AKT signaling coordinates with impaired insulin secretion and insulin resistance, identified during T2D, obesity and cardiovascular disorders which brings in the relevance of PHLPPs in the metabolic paradigm. In this review, we discuss the impact of PHLPP...

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PMID: 28428363
DOI: 10.1530/joe-17-0081

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