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Article

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Diabetes - 1 Jun 2014

Cnop Miriam, Abdulkarim Baroj, Bottu Guy, Cunha Daniel A, Igoillo-Esteve Mariana, Masini Matilde, Turatsinze Jean-Valery, Griebel Thasso, Villate Olatz, Santin Izortze, Bugliani Marco, Ladriere Laurence, Marselli Lorella, McCarthy Mark I, Marchetti Piero, Sammeth Michael, Eizirik Décio L

Abstract excerpt

Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA sequencing to map transcripts expressed in five palmitate-treated human islet preparations, observing 1,325 modified genes. Palmitate induced fatty acid metabolism and endoplasmic...

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Share to Diabetes Mellitus, Type 2
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Inflammation

Share to Islets of Langerhans

Share to Palmitates

Share to Sequence Analysis, RNA

Share to Transcriptome

Source

Identifiers

PMID: 24379348
DOI: 10.2337/db13-1383

Genes

PAX4
ATF6
GATA6
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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