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Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

21 May 2008

Abstract excerpt

The prevalence of Type 2 diabetes is increasing dramatically as a result of the obesity epidemic, and poses a major health and socio-economic burden. Type 2 diabetes develops in individuals who fail to compensate for insulin resistance by increasing pancreatic insulin secretion. This insulin deficiency results from pancreatic beta-cell dysfunction and death. Western diets rich in saturated fats cause obesity and...

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PMID: 18481955
DOI: 10.1042/bst0360348

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