Article

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell Dysfunction

2024-07-19

Abstract excerpt

Chronically elevated circulating excess free fatty acids ( i.e. lipotoxicity) is a pathological process implicated in several metabolic disorders, including obesity-driven Type 2 diabetes (T2D). Lipotoxicity exerts detrimental effects on pancreatic islet β-cells by reducing glucose-stimulated insulin secretion (GSIS), altering β-cell transcriptional identity, and promoting apoptosis. While β-cell-derived small ex...

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Literature Corpus work: f9b57007-35a8-59ba-9e68-e56b4e496f40
DOI: 10.1101/2024.07.19.604353

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