Article
Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
The Journal of clinical investigation - 1 Mar 2018
Ye Risheng, Gordillo Ruth, Shao Mengle, Onodera Toshiharu, Chen Zhe, Chen Shiuhwei, Lin Xiaoli, SoRelle Jeffrey A, Li Xiaohong, Tang Miao, Keller Mark P, Kuliawat Regina, Attie Alan D, Gupta Rana K, Holland William L, Beutler Bruce, Herz Joachim, Scherer Philipp E
Abstract excerpt
The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell compensation and lipid metabolism upon obesity and peripheral insulin resistance, we eliminated LDL receptor-related...
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