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Article

Glycogen synthase kinase-3β genetic polymorphisms and insomnia in depressed patients: A prospective study.

Journal of affective disorders - 1 Nov 2018

Costemale-Lacoste Jean-François, Colle Romain, Martin Séverine, Asmar Khalil El, Loeb Emanuel, Feve Bruno, Verstuyft Céline, Trabado Séverine, Ferreri Florian, Haffen Emmanuel, Polosan Mircea, Becquemont Laurent, Corruble Emmanuelle

Abstract excerpt

BACKGROUND: 80-90% of patients with Major Depressive Episode (MDE) experience insomnia and up-to 50% severe insomnia. Glycogen Synthase Kinase-3β (GSK3B) is involved both in mood regulation and circadian rhythm. Since GSK3B polymorphisms could affect protein levels or functionality, we investigated the association of GSK3B polymorphisms with insomnia in a sample of depressed patients treated with antidepressants....

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PMID: 30081294
DOI: 10.1016/j.jad.2018.07.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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