Article
A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression.
Neuroscience letters - 23 Sept 2004
Benedetti Francesco, Serretti Alessandro, Colombo Cristina, Lorenzi Cristina, Tubazio Viviana, Smeraldi Enrico
Abstract excerpt
The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP) (-50T/C) falling into the effective promoter region (nt -171 to +29) of the gene coding for glycogen synthase kinase 3-beta (GSK3-beta) has been linked with different age at onset of bipolar illness. GSK3-beta codes for an enzyme which...
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