Article
Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder.
Archives of general psychiatry - 1 Jul 2009
Inkster Becky, Nichols Thomas E, Saemann Philipp G, Auer Dorothee P, Holsboer Florian, Muglia Pierandrea, Matthews Paul M
Abstract excerpt
CONTEXT: Indirect evidence suggests that the glycogen synthase kinase-3beta (GSK3beta) gene might be implicated in major depressive disorder (MDD). BACKGROUND: We evaluated 15 GSK3beta single-nucleotide polymorphisms (SNPs) to test for associations with regional gray matter (GM) volume differences in patients with recurrent MDD. We then used the defined regions of interest based on significant associations to...
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