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Article

Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder.

The pharmacogenomics journal - 1 Dec 2008

Tsai S-J, Liou Y-J, Hong C-J, Yu Y W-Y, Chen T-J

Abstract excerpt

Evidence suggests that glycogen synthase kinase-3beta (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD). Inhibition of GSK3B is thought to be a key feature in the therapeutic mechanism of antidepressants. To investigate whether common genetic variants in the GSK3B gene are associated with MDD and the therapeutic response to antidepressants, four...

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Identifiers

PMID: 18195729
DOI: 10.1038/sj.tpj.6500486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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