Article
Association between glycogen synthase kinase-3beta gene polymorphisms and major depression and suicidal behavior in a Korean population.
Progress in neuro-psychopharmacology & biological psychiatry - 17 Mar 2010
Yoon Ho-Kyoung, Kim Yong-Ku
Abstract excerpt
BACKGROUND: Glycogen synthase kinase (GSK)-3beta plays a key role in the phosphorylation and regulation of metabolic enzymes and many transcription factors. Several lines of evidence implicate GSK-3beta in the pathophysiology of mood disorders and susceptibility to suicidal behavior. In this study, we aimed to investigate the GSK-3beta gene's association with major depressive disorder (MDD) and suicidal behavior....
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