The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders.

doi:10.1016/j.jad.2017.02.023

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Article

The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders.

Journal of affective disorders - 15 Apr 2017

Bureau Alexandre, Beaulieu Jean Martin, Paccalet Thomas, Chagnon Yvon C, Maziade Michel

Abstract excerpt

BACKGROUND: Previous evidence in healthy subjects suggested that functional polymorphisms GSK3B rs12630592 and FXR1 rs496250 interact in regulating mood and emotional processing. We attempted to replicate this interaction primarily on manic and depressive dimensions in mood disorder patients, and secondarily on schizophrenia patients, diagnosis itself and age of onset. METHODS: Symptom dimensions were derived...

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PMID: 28242499
DOI: 10.1016/j.jad.2017.02.023

Genes

FXR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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