Article
GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis.
Molecular neurobiology - 1 Dec 2013
Tang Hui, Shen Na, Jin Huijuan, Liu Dan, Miao Xiaoping, Zhu Ling-Qiang
Abstract excerpt
Glycogen synthase kinase 3 (GSK-3) is a well-known conserved and ubiquitous protein kinase and playing a pivotal role in neurodevelopment, neurogenesis, learning/memory, and neuronal cell death. Dysfunction of GSK-3 had been seen in multiple neurodegenerative and psychiatric diseases. Bipolar disorder and schizophrenia are two common psychiatric diseases first occur in adolescence or young adulthood. They share...
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