Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity.

Biomolecules - 1 Aug 2018

Angelova Dafina M, Brown David R

Abstract excerpt

Aging is the most prominent risk factor for most neurodegenerative diseases. However, incorporating aging-related changes into models of neurodegeneration rarely occurs. One of the significant changes that occurs in the brain as we age is the shift in phenotype of the resident microglia population to one less able to respond to deleterious changes in the brain. These microglia are termed dystrophic microglia. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Cell Death
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Microglia

Share to Neurodegenerative Diseases

Share to Protein Aggregates

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 30071596
DOI: 10.3390/biom8030067
PMCID: PMC6164966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity.PMID 30071596Read ↗

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent MicrogliaSemantic proximity Read ↗

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microgliaSemantic proximity Read ↗

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microgliaSemantic proximity Read ↗

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.Semantic proximity Read ↗

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.Semantic proximity Read ↗

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration.Semantic proximity Read ↗

Dystrophic microglia are a disease associated microglia morphology in the human brainSemantic proximity Read ↗

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.Semantic proximity Read ↗

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.Semantic proximity Read ↗

Immunoregulation of Microglia M2 polarization is an unrecognized physiological function of α -SynucleinSemantic proximity Read ↗

The Hallmarks of Ageing in MicrogliaSemantic proximity Read ↗

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease RiskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.