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Article

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.

Journal of neuroinflammation - 9 May 2011

Rojanathammanee Lalida, Murphy Eric J, Combs Colin K

Abstract excerpt

BACKGROUND: Increased reactive microglia are a histological characteristic of Parkinson's disease (PD) brains, positively correlating with levels of deposited α-synuclein protein. This suggests that microglial-mediated inflammatory events may contribute to disease pathophysiology. Mutations in the gene coding for α-synuclein lead to a familial form of PD. Based upon our prior findings that α-synuclein expression...

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Identifiers

PMID: 21554732
DOI: 10.1186/1742-2094-8-44
PMCID: PMC3104357

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