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Article

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia

27 Jul 2018

Abstract excerpt

The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact with. We have developed a model microglia system that recapitulates the dystrophic/senescent phenotype, and we have combined this with the study of β-amyloid processing. The model is based on...

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PMID: 30052418
DOI: 10.1021/acschemneuro.8b00334

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