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Article

GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.

Scientific reports - 30 Jul 2018

Tutunea-Fatan Elena, Abd-Elrahman Khaled S, Thibodeau Jean-Francois, Holterman Chet E, Holleran Brian J, Leduc Richard, Kennedy Christopher R J, Gros Robert, Ferguson Stephen S G

Abstract excerpt

The renin-angiotensin system regulates blood pressure and fluid balance in the body primarily via angiotensin receptor 1 (AT1R). Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension. G protein-coupled receptor kinase 2 (GRK2) modulates AT1R desensitization and increased GRK2 protein expression is reported in hypertensive patients. However, the consequences of GRK2 inhibition on kidney...

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Identifiers

PMID: 30061705
DOI: 10.1038/s41598-018-29876-8
PMCID: PMC6065385

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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