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Article

Liver angiotensinogen is the primary source of renal angiotensin II.

Journal of the American Society of Nephrology : JASN - 1 Jul 2012

Matsusaka Taiji, Niimura Fumio, Shimizu Akihiro, Pastan Ira, Saito Akihiko, Kobori Hiroyuki, Nishiyama Akira, Ichikawa Iekuni

Abstract excerpt

Angiotensin II content in the kidney is much higher than in the plasma, and it increases more in kidney diseases through an uncertain mechanism. Because the kidney abundantly expresses angiotensinogen mRNA, transcriptional dysregulation of angiotensinogen within the kidney is one potential cause of increased renal angiotensin II in the setting of disease. Here, we observed that kidney-specific angiotensinogen...

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Identifiers

PMID: 22518004
DOI: 10.1681/ASN.2011121159
PMCID: PMC3380650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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