Article
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice.
American journal of physiology. Renal physiology - 1 Jan 2001
Saavedra J M, Häuser W, Ciuffo G, Egidy G, Hoe K L, Jöhren O, Sembonmatsu T, Inagami T, Armando I
Abstract excerpt
The proposed feedback between angiotensin II AT(2) and AT(1) receptors prompted us to study AT(1) receptor expression in kidneys of male AT(2) receptor-gene disrupted mice (agtr2 -/y). In wild-type (agtr2 +/y) mice, AT(1) receptor binding and mRNA is abundant in glomeruli, and AT(1) receptor binding is also high in the inner stripe of the outer medulla. AT(2) receptors are scarce, primarily associated to cortical...
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