Article
The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.
PloS one - 1 Jan 2021
Meagher Patrick, Civitarese Robert, Lee Xavier, Gordon Mark, Bugyei-Twum Antoinette, Desjardins Jean-Francois, Kabir Golam, Zhang Yanling, Kosanam Hari, Visram Aylin, Leong-Poi Howard, Advani Andrew, Connelly Kim A
Abstract excerpt
BACKGROUND: Patients with diabetes are at a high risk for developing cardiac dysfunction in the absence of coronary artery disease or hypertension, a condition known as diabetic cardiomyopathy. Contributing to heart failure is the presence of diabetic kidney disease. The Goto-Kakizaki (GK) rat is a non-obese, non-hypertensive model of type 2 diabetes that, like humans, shares a susceptibility locus on chromosome...
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