Article
Genetic manipulation and genetic variation of the kallikrein-kinin system: impact on cardiovascular and renal diseases.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques - 1 Jan 2014
Girolami Jean-Pierre, Blaes Nelly, Bouby Nadine, Alhenc-Gelas François
Abstract excerpt
Genetic manipulation of the kallikrein-kinin system (KKS) in mice, with either gain or loss of function, and study of human genetic variability in KKS components which has been well documented at the phenotypic and genomic level, have allowed recognizing the physiological role of KKS in health and in disease. This role has been especially documented in the cardiovascular system and the kidney. Kinins are produced...
Topics
- Animals
- Cardiovascular Agents
- Cardiovascular Diseases
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Kallikreins
- Kidney Diseases
- Kinins
- Phenotype
- Renal Agents
- Signal Transduction