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Article

Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation.

Kidney international - 1 May 2014

Matsusaka Taiji, Niimura Fumio, Pastan Ira, Shintani Ayumi, Nishiyama Akira, Ichikawa Iekuni

Abstract excerpt

Intrarenal angiotensin II is increased in kidney diseases independently of plasma angiotensin II and is thought to promote progressive deterioration of renal architecture. Here we investigated the mechanism of enhanced renal angiotensin II generation in kidney glomerular diseases. For this, kidney- or liver-specific angiotensinogen gene (Agt) knockout was superimposed on the mouse model of inducible podocyte...

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Identifiers

PMID: 24284520
DOI: 10.1038/ki.2013.453
PMCID: PMC7681568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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