Article
Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2002
Goto Masahisa, Mukoyama Masashi, Sugawara Akira, Suganami Takayoshi, Kasahara Masato, Yahata Kensei, Makino Hisashi, Suga Shinichi, Tanaka Issei, Nakao Kazuwa
Abstract excerpt
Angiotensin II type 2 (AT2) receptor is developmentally regulated and exerts antiproliferative and proapoptotic actions. Genetic ablation of this receptor in mice affects regulation of blood pressure, but the involvement of the AT2 receptor in the pathogenesis of hypertension remains unknown. In the present study, we examined developmental changes of angiotensin receptor subtypes in the kidney of stroke-prone...
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