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Article

Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2021

Perry Daniel J, Peters Leeana D, Lakshmi Priya Saikumar, Zhang Lin, Han Zhao, Wasserfall Clive H, Mathews Clayton E, Atkinson Mark A, Brusko Todd M

Abstract excerpt

A missense mutation (R620W) of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), which encodes lymphoid-tyrosine phosphatase (LYP), confers genetic risk for multiple autoimmune diseases including type 1 diabetes. LYP has been putatively demonstrated to attenuate proximal T and BCR signaling. However, limited data exist regarding PTPN22 expression within primary T cell subsets and the impact of the type 1...

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Source

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Identifiers

PMID: 34301848
DOI: 10.4049/jimmunol.2000708
PMCID: PMC8323970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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