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Article

Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis.

Frontiers in public health - 1 Jan 2023

Peng Aiyu, Gong Chunmei, Xu Yuanfei, Liang Xiongshun, Chen Xiaoping, Hong Wenxu, Yan Junxia

Abstract excerpt

Background: Variants in organic cation transporter (OCT) genes play a crucial role in metformin pharmacokinetics and are critical for diabetes treatment. However, studies investigating the effect of OCT genetic polymorphisms on metformin response have reported inconsistent results. This review and meta-analysis aimed to evaluate the associations between OCT genetic polymorphisms and metformin response and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37546319
DOI: 10.3389/fpubh.2023.1183879
PMCID: PMC10400771

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Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis.PMID 37546319Read ↗

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