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Article

Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling

20 Jan 2018

Abstract excerpt

Cancer is composed of multiple cell populations with different genomes. This phenomenon called intratumor heterogeneity (ITH) is supposed to be a fundamental cause of therapeutic failure. Therefore, its principle-level understanding is a clinically important issue. To achieve this goal, an interdisciplinary approach combining genome analysis and mathematical modeling is essential. For example, we have recently...

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PMID: 29352488
DOI: 10.1111/cas.13510

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