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Article

Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.

Molecular oncology - 1 Feb 2017

Suzuki Yuka, Ng Sarah Boonhsi, Chua Clarinda, Leow Wei Qiang, Chng Jermain, Liu Shi Yang, Ramnarayanan Kalpana, Gan Anna, Ho Dan Liang, Ten Rachel, Su Yan, Lezhava Alexandar, Lai Jiunn Herng, Koh Dennis, Lim Kiat Hon, Tan Patrick, Rozen Steven G, Tan Iain Beehuat

Abstract excerpt

Intratumor heterogeneity (ITH) contributes to cancer progression and chemoresistance. We sought to comprehensively describe ITH of somatic mutations, copy number, and transcriptomic alterations involving clinically and biologically relevant gene pathways in colorectal cancer (CRC). We performed multiregion, high-depth (384× on average) sequencing of 799 cancer-associated genes in 24 spatially separated primary...

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Identifiers

PMID: 28145097
DOI: 10.1002/1878-0261.12012
PMCID: PMC5527459

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APC
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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