Article
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development
9 Sept 2022
Abstract excerpt
Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We...
Topics
Join the communities discussing this publication.