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Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

9 Sept 2022

Abstract excerpt

Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We...

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PMID: 36085309
DOI: 10.1038/s42003-022-03884-x

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