Article
Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.
PLoS genetics - 1 Feb 2016
Uchi Ryutaro, Takahashi Yusuke, Niida Atsushi, Shimamura Teppei, Hirata Hidenari, Sugimachi Keishi, Sawada Genta, Iwaya Takeshi, Kurashige Junji, Shinden Yoshiaki, Iguchi Tomohiro, Eguchi Hidetoshi, Chiba Kenichi, Shiraishi Yuichi, Nagae Genta, Yoshida Kenichi, Nagata Yasunobu, Haeno Hiroshi, Yamamoto Hirofumi, Ishii Hideshi, Doki Yuichiro, Iinuma Hisae, Sasaki Shin, Nagayama Satoshi, Yamada Kazutaka, Yachida Shinichi, Kato Mamoru, Shibata Tatsuhiro, Oki Eiji, Saeki Hiroshi, Shirabe Ken, Oda Yoshinao, Maehara Yoshihiko, Komune Shizuo, Mori Masaki, Suzuki Yutaka, Yamamoto Ken, Aburatani Hiroyuki, Ogawa Seishi, Miyano Satoru, Mimori Koshi
Abstract excerpt
Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in...
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