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Article

Tumour heterogeneity and evolutionary dynamics in colorectal cancer

16 Jul 2021

Abstract excerpt

Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progressed from initial discoveries which focused on the stepwise accumulation of key driver mutations, as encapsulated in the Vogelstein model, to one in which marked heterogeneity leads to a complex interplay between clonal populations. Current evidence suggests that an initial explosion, or "Big Bang", of genetic...

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PMID: 34272358
DOI: 10.1038/s41389-021-00342-x

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