Article
Receptor-Arrestin Interactions: The GPCR Perspective.
Biomolecules - 4 Feb 2021
Seyedabadi Mohammad, Gharghabi Mehdi, Gurevich Eugenia V, Gurevich Vsevolod V
Abstract excerpt
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins, facilitating receptor internalization, and initiating distinct arrestin-mediated signaling. The molecular mechanism of arrestin-GPCR interactions has been extensively...
Topics
- Animals
- Arrestin
- Arrestins
- Binding Sites
- Cattle
- Crystallography, X-Ray
- Fishes
- Humans
- Hydrophobic and Hydrophilic Interactions
- Mice
- Models, Molecular
- Mutation