Article
Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.
Cellular signalling - 1 Oct 2005
Gripentrog Jeannie M, Miettinen Heini M
Abstract excerpt
G protein-coupled receptors (GPCRs) transmit diverse cellular signals in response to a large number of stimuli such as chemoattractants, lipids, neurotransmitters, odorants and light. The classical signaling pathway is through heterotrimeric G proteins, but GPCRs can also transmit signals through mechanisms that are not dependent on G proteins. In mammalian cells, the key component for this type of signaling is...
Topics
- Animals
- Arrestins
- CHO Cells
- Calcium
- Calcium Signaling
- Cell Membrane
- Cell Nucleus
- Chemotaxis
- Cricetinae
- Cricetulus
- Cytosol
- Endocytosis
- Enzyme Activation
- GTP-Binding Proteins