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Article

Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq.

Molecular pharmacology - 1 Oct 2003

Ally Roxanne A, Ives Kirk L, Traube Elie, Eltounsi Iman, Chen Pei-Wen, Cahill Patrick J, Battey James F, Hellmich Mark R, Kroog Glenn S

Abstract excerpt

Acute desensitization of many guanine nucleotide-binding protein-coupled receptors (GPCRs) requires receptor phosphorylation and subsequent binding of an arrestin. GPCRs are substrates for phosphorylation by several classes of kinases. Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent...

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Identifiers

PMID: 14500746
DOI: 10.1124/mol.64.4.890

Genes

GRK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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