Article
Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq.
Molecular pharmacology - 1 Oct 2003
Ally Roxanne A, Ives Kirk L, Traube Elie, Eltounsi Iman, Chen Pei-Wen, Cahill Patrick J, Battey James F, Hellmich Mark R, Kroog Glenn S
Abstract excerpt
Acute desensitization of many guanine nucleotide-binding protein-coupled receptors (GPCRs) requires receptor phosphorylation and subsequent binding of an arrestin. GPCRs are substrates for phosphorylation by several classes of kinases. Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Arrestin
- Biological Transport
- Bombesin
- Calcium
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinase C